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  • YEAR
    • 2017
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sector_ico_Health_trans Human Health
Defining the Mouse Cytome...

The International Mouse Phenotyping Consortium (IMPC) is a $500 million world-wide partnership of research institutions focused on understanding the function of every gene in the m...

May 25, 2021
sector_ico_Health_trans Human Health
Development of a non-invasive, digital PCR-based molecular test for ri...

Oral cancer (OC) is a global health problem with high incidence and high mortality. OC has worldwide impact, accounting for 274,000 new cases and 145,000 deaths each year. The 5 ye...

May 25, 2021
sector_ico_Health_trans Human Health
BC Wild Mushrooms – Developing a Library of Chemical Fractions f...

Mushrooms have been used as a source of traditional medicine for thousands of years by different cultures around the world. However, it is estimated that only 10% of mushroom speci...

May 25, 2021
sector_ico_Environment_trans Environment
Deep Sequencing of Marine Biodiversity: Speciation Genes in Sea Stars...

This project extends a previous Genome BC SOF aimed to identify speciation genes in an iconic BC sea star. The  focus of this work was on analyzing speciation genes that cause...

May 25, 2021
Data and Technology
Advanced Assembly Assessment and Annotation...

This project built on past expertise to remedy a strategic gap in the availability of actively supported, scalable bioinformatics tools for genome assembly. The first objective was...

May 25, 2021
sector_ico_Health_trans Human Health
Modeling Human Lymphoma Mutations in Mice...

Next-generation sequencing has made it feasible to sequence cancer genomes to determine the underlying genetic causes of the disease. The objective of this project was to establis...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
Molecular and physiological characterization of early ripening events ...

Grapevine is one of the most widely cultivated fruit crops. Despite its importance in determining fruit and wine economic value, the regulation of fruit ripening at a molecular lev...

May 25, 2021
sector_ico_Health_trans Human Health
Metagenomic analysis of lung infiltrates in patients with leukemia...

Patients with neutropenia (an abnormally low level of neutrophils) are at a high risk for life-threatening bacterial and/or fungal infections after high-dose chemotherapy for acute...

May 25, 2021
Data and Technology sector_ico_Environment_trans Environment
Single Virus Genomics: Adoption and Optimization of Single Cell Techno...

Viruses are by far the most abundant "lifeforms" in the oceans and are the reservoir of most of the genetic diversity in the sea. Every second, approximately 1023 viral infections ...

May 25, 2021
sector_ico_Health_trans Human Health
Harnessing cladoniamide biosynthesis for colon cancer therapy...

Cladoniamides represent an important new class of anticancer drugs with nanomolar inhibition of tumor cell line growth. However, they are difficult to synthesize as a natural produ...

May 25, 2021
sector_ico_Health_trans Human Health
Development of an actionable molecular test for risk assessment of ora...

Oral cancer is a global health problem with high incidence and poor mortality, and the presence and degree of dysplasia remain the gold standard for cancer progression. Approximate...

May 25, 2021
sector_ico_Health_trans Human Health
Synergizing -omics to discover treatable intellectual disabilities...

Intellectual disability (ID) is a lifelong, debilitating condition affecting 2.5% of children and adults worldwide. Most IDs are of genetic origin, but causal variants are identifi...

May 25, 2021
sector_ico_Health_trans Human Health
Bioinformatic Identification of Optimal Targets and Therapeutic Antibo...

This project aimed to develop a computational approach to identify potential therapeutic opportunities by examining protein coding changes across a large number of tumours sequence...

May 25, 2021
sector_ico_Environment_trans Environment
Simplifying Complex Genome Generation...

Ranidae/Bullfrogs are the "true frogs" that have the widest global distribution. As the largest amphibian family, bullfrogs have an undeniable role as sentinel species, food source...

May 25, 2021
sector_ico_Health_trans Human Health
Using Science, Technology, and Society Studies Research to Move Genomi...

Using BC’s genomics research and business sector as the site for applied research, this project aimed to address data integration issues faced when integrating data from mult...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Detecting and Characterizing Chimeric Transcripts in Mouse Tissues...

Chimeric transcriptions are newly discovered genetic events that do not correlate with the current model for gene expression and have potential impacts and application in cancer di...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
Vaccinomics for animal disease...

Infectious diseases continue to be a leading cause of morbidity and mortality in domestic animals and are of significant concern to human health due to the potential for the transf...

May 25, 2021
sector_ico_Health_trans Human Health
Antisense PET Imaging of mRNA Expression Using F-18 Labeled CPP-PNA an...

Molecular imaging (MI) is a powerful tool that probes the function of living systems, enabling non-invasive determination of physiological changes that occur during the onset and p...

May 25, 2021
sector_ico_Health_trans Human Health
Development of a high-throughput platform to rapidly translate genomic...

Studies have revealed that cancers typically contain tens to hundreds of mutations, which often differ between patients. While the prospect of targeting this huge diversity of muta...

May 25, 2021
Data and Technology sector_ico_Environment_trans Environment
Population transcriptomics- harnessing next-generation sequencing tech...

This project used a genomic approach to understand the impacts of rapid climate change and to aid species at risk. Some species of fish in BC have recently demonstrated the ability...

May 25, 2021
sector_ico_Health_trans Human Health
Linking Infectious Agents and Cancer – A Metagenomics Approach...

Multiple factors can contribute to the development of cancer including lifestyle choices, diet, environment and family history. Surprisingly, more than 20% of cancer cases worldwid...

May 25, 2021
sector_ico_Health_trans Human Health
Using Methods of Chemical Genomics for Developing Potent Androgen Rece...

These research projects aim to address current issues in the treatment of advanced, recurrent or metastatic prostate cancer. By using advanced methods in computational chemogenomic...

May 25, 2021
sector_ico_Health_trans Human Health
Development of a gene expression-based high-throughput screening platf...

The human immune system is highly responsive yet tightly controlled - it must be able to respond appropriately to new threats like infections and viruses, but at the same time must...

May 25, 2021
sector_ico_Health_trans Human Health
Functional Characterization of the Transcriptional Network Driving Mam...

Normal brain development is a very complex process that involves many discrete, sequential events. When the order or timing of these brain development events is not perfect, severe...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Development of a high-throughput proteomics platform for biomarker ver...

This project enabled the rapid detection and measurement of proteins in human plasma. The team developed methods to measure a panel of 67 biomarkers, which have been proposed to di...

May 25, 2021
sector_ico_Health_trans Human Health
Characterizing a bacterial recombinome...

These projects investigated bacterial genomics with the intent of developing new tools to uncover the mechanisms by which they can become more pathogenic. Genetic recombination is ...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Rapid Evolution of a clinical high-throughput DNA sequencing pipeline ...

Recent developments in DNA sequencing technologies have changed the way scientists collect and interpret genomic data as these “next-generation sequencers” can generate...

May 25, 2021
sector_ico_Health_trans Human Health
Optimization of Pyruvate Kinase Inhibitor Lead Compounds as Novel Ther...

Multidrug-resistant (MDR) strains of bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) are becoming more prominent in BC’s hospitals and community settings....

May 25, 2021
sector_ico_Forestry_trans Forestry
The application of high throughput DNA sequencing in the identificatio...

The realities of global warming and the volatile oil market have triggered a movement to replace part of the fossil fuel reliance with renewable fuels. A solution was proposed to u...

May 25, 2021
sector_ico_Health_trans Human Health
Splice-Variant Profiling of Voltage-Gated Calcium Channels- Implicatio...

Calcium channels are an important target for the therapeutic treatment of several human disorders including migraine, epilepsy, chronic pain, mood disorders, heart disease and cert...

May 25, 2021
sector_ico_Forestry_trans Forestry
Barcoding of BC Ectomycorrhizal Mushrooms...

This project looked at the diversity of fungal populations that can inform forest management practices to protect diversity in BC, the most biologically diverse province in the cou...

May 25, 2021
sector_ico_Environment_trans Environment
Environmental Genomics of RNA Viruses...

The premise of this project was to obtain the first survey of the diversity and composition of the virus assemblages found in the migratory bird ponds using high throughput sequenc...

May 25, 2021
sector_ico_Forestry_trans Forestry
Conifer Hybrid Zones as Genomic Laboratories for Adaptation to New Cli...

This small scale project looked at results generated from previous investment in the Treenomix project looking at variability in adaption of spruce. Researchers tested the utility ...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
PCR-free, Sequence-specific Nucleic Acid Detection...

Nucleic acid diagnostics hold tremendous promise for clinical application that remains largely unfulfilled by the complexity, cost, and unreliability of PCR based detection methods...

May 25, 2021
sector_ico_Environment_trans Environment
Time Resolved Community Genomics of Subarctic Pacific Oxygen Minimum Z...

This project seeks to understand the oceanic microbial communities and the effect these have on oxygen concentrations in the oceans' “dead zones”; a critical element to...

May 25, 2021
sector_ico_Forestry_trans Forestry
Conifer Genome Exploration...

This project explored the genome organization, structure and sequence of two conifer species: white spruce and loblolly pine. Previously, no conifer genome sequencing project had b...

May 25, 2021
sector_ico_Environment_trans Environment
FrogSCOPE (frog Sentinel species Comparative...

Frogs provide a very sensitive biological sensor of dangerous chemicals because of the drastic morphological changes that happen during the transition between tadpole and frog life...

May 25, 2021
sector_ico_Environment_trans Environment
Development of a Health Assessment Tool for Marine Mussels (Myt-OME)...

Increasing environmental pressures on the BC coastline have affected both coastal habitats and the productivity of the aquaculture industry. Unexplained shellfish mortality at four...

May 25, 2021
sector_ico_Health_trans Human Health
Flow Sorting Facility at BC Cancer Agency...

Genome sequencing of any biological sample invariably involves a homogeneous mixture of cells and cell types, but by studying single cells, the confusion that accompanies these mix...

May 25, 2021
sector_ico_Health_trans Human Health
Chemical suppressors of nonsense mutations for the treatment of geneti...

Precise molecular lesions responsible for ~5,000 rare genetic diseases that afflict Canadians. Unfortunately, most of these diseases have no treatments, about 30% of patients die i...

May 25, 2021
sector_ico_Health_trans Human Health
Simultaneous Lung and Cardiac Gated Radiotherapy using Electrical Impe...

The motion of organs due to respiration and cardiac contraction is a major concern during both medical imaging and radiation treatment. The commercially available respiratory and c...

May 25, 2021
Data and Technology
Pre-commercial development of high-performance microfluidic single-cel...

The project focused on developing new methods of performing preimplantation genetic diagnosis (PGD), which is the genetic testing of multiple embryos created by in vitro fertilizat...

May 25, 2021
sector_ico_Health_trans Human Health
Intravesical Docetaxel Formulation for the Treatment of Ta/T1 Stage Bl...

Bladder cancer is the fourth most prevalent cancer in the US in men (ninth in women) with an overall mortality of 20%. It has the highest lifetime treatment cost per patient as wel...

May 25, 2021
sector_ico_Health_trans Human Health
New Peptide Therapeutic for Treatment of Addiction...

Substance abuse and addiction represent a huge burden to society and the need for effective addiction medications is urgent. There are not any approved therapies for many types of ...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Pre-commercial Development of Single Cell Monoclonal Antibody Selectio...

Building upon their established single-cell microfluidic methods and capabilities to enable the rapid, high-throughput selection of monoclonal antibodies (mAbs) for therapeutic and...

May 25, 2021
sector_ico_Health_trans Human Health
Minimally Invasive Curved Intramedullary Fixation for the Pelvis...

Open surgical access to the interior surface of the pelvis is invasive and inherently risky due to the concentration of blood vessels and nerves in the area. In response, researche...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Use of the Ion Torrent Next Generation Sequencing Platform for Rapid a...

Childhood solid malignant tumors often present as soft tissue masses with undifferentiated small round cells under microscopic examination. The primitive features of these tumors o...

May 25, 2021
sector_ico_Health_trans Human Health
Identification of Novel Broad-Spectrum Drug Targets and Small Molecule...

The project aimed at addressing the ongoing issue of multidrug-resistant (MDR) bacterial pathogens. The main goal of this project was to identify novel drug targets and therapeutic...

May 25, 2021
sector_ico_Health_trans Human Health
New chemical tools for enriching and analyzing epigenetic signatures...

It has been shown that a family of macrocyclic molecules has high affinity and specificity for methylated lysines — epigenetic/gene regulation marks that are especially impor...

May 25, 2021
sector_ico_Health_trans Human Health
Chemogenomics-Driven Advancement of a Novel Class of Anti-Androgen The...

These research projects aim to address current issues in the treatment of advanced, recurrent or metastatic prostate cancer. By using advanced methods in computational chemogenomic...

May 25, 2021
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