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  • YEAR
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sector_ico_Health_trans Human Health
OnTarget: Big Data Informed Software for the Design of cis-Regulatory ...

All cells of the human body have the same DNA sequences (genes) that “code” for the body’s entire diversity of cell types, from blood to brain, liver, muscle and ...

May 25, 2021
sector_ico_Health_trans Human Health
Precision Medicine CanPREVENT AMR- Applying Precision Medicine Technol...

The Canadian kidney transplant system has traditionally relied on list-based and geographic criteria to allocate organs, despite compelling evidence that genetic human le...

May 25, 2021
sector_ico_Environment_trans Environment
Bacterial Source Tracking to improve the health of two urban streams i...

The City of Vernon is challenged by degradation of its urban streams due to fecal contamination of surface water used for drinking and recreation. Current testing practices, such a...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
Genomic Analysis of Wetland Sediment as a Tool for Avian Influenza Sur...

Avian Influenza (AI) is a viral disease that can cause significant morbidity and mortality in domestic poultry. AI outbreaks, and associated eradication efforts, have negative impa...

May 25, 2021
sector_ico_Health_trans Human Health
Implementing Genomics in the Neonatal Period...

The neonatal intensive care unit (NICU) at BC Women’s Hospital + Health Centre cares for approximately 1,200 premature or ill infants annually. Many have underlying genetic d...

May 25, 2021
sector_ico_Health_trans Human Health
Modeling and Therapeutic Targeting of the Clinical and Genetic Diversi...

Glioblastoma (GBM) is a deadly brain cancer that has eluded major treatment advances. New therapies for GBM are needed, however there is no consensus on how best to find them. The ...

May 25, 2021
sector_ico_Health_trans Human Health
GEL-GBC Rare Disease Pilot Study...

More than 80 per cent of the 7000 known rare diseases are genetic in origin. Genetic disorders of children are individually rare but collectively frequent, affecting the lives of a...

May 25, 2021
sector_ico_Forestry_trans Forestry
Connecting Genomics with First Nations values and interests- Developme...

This project was a collaborative initiative that developed original multimedia online educational materials tailored to the British Columbia (BC) high school science curriculum on ...

May 25, 2021
sector_ico_Health_trans Human Health
Clinical Assessment of the Utility of Sequencing and Evaluation as a S...

The BC Provincial Health Services Authority (PHSA), introduced a 3-year pilot program [the Clinical Assessment of the Utility of Sequencing and Evaluation as a Service (CAUSES) Cli...

May 25, 2021
sector_ico_Energy_trans Energy
Microbial community structure and dynamics associated with controlled ...

One of the pillars of British Columbia’s bioenergy strategy requires the use of blended biofuels including ethanol, methanol and biodiesel. Despite the promise of using blend...

May 25, 2021
sector_ico_Environment_trans Environment
Subsurface microbiome responses to fugitive natural gas...

Unconventional natural gas resource development risks releasing fugitive gas into groundwater and/or the atmosphere due to wellbore integrity failure. These leaks may affect ground...

May 25, 2021
sector_ico_Environment_trans Environment
Understanding the algal microbiomes living on alpine snowfields in sou...

Snow in alpine and polar regions takes on a pinkish hue during the summertime. This “watermelon snow” or “red snow" is caused by blooms of microscopic algae ...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
Genomics of viruses and microbial symbionts of spotted wing Drosophila...

Spotted wing Drosophila (SWD), an invasive insect pest, lays its eggs in berries and other small fruits causing them to rot. In BC, ~25% of SWD harbor an intracellular symbiotic ba...

May 25, 2021
Data and Technology
AnnoVis- Annotation and visualization of de novo genome and transcript...

Establishing a fundamental understanding of the specific molecular biology of a species begins with reconstructing its genome (DNA) and transcriptome (RNA). Assembling the large vo...

May 25, 2021
sector_ico_Environment_trans Environment
Global scale metabolic pathway reconstruction from environmental genom...

For more than 3.5 billion years, microorganisms have been the dominant form of life on Earth, mediating global fluxes of matter and energy. Over the past decade, high-throughput om...

May 25, 2021
Data and Technology
Bioinformatics Tools to Enable Federated, Real Time Genomic Epidemiolo...

Infectious diseases can devastate both animal and human lives, damage economies and paralyze trade. The One Health approach recognizes that the health of humans, animals and the en...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
Examining Public Beliefs about the Ethics of Genetically Modifying Liv...

This project aimed to understand societal concerns around the acceptability of Genetically Modified (GM) technology applied to animal agriculture, and how these conc...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
The Regulatory Environment for Gene-Edited Crops: A Cross-National Com...

Recently, claims have arisen that “GM 2.0” has arrived, bringing a suite of new Gene Editing (GE) techniques that supercharge existing and well-known genetic modificati...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
Understanding the Perceived Risks and Benefits of Agricultural Applica...

Our food system faces major challenges—in particular, adapting to climate change and feeding a growing global population. Recently, gene editing (GE) technologies have made i...

May 25, 2021
sector_ico_Health_trans Human Health
Biomarkers for Crossing the Translational Divide in Acute Spinal Cord ...

There are currently no neuro-restorative treatments for acute spinal cord injury (SCI). The few promising experimental therapies for SCI that have been translated to humans have fa...

May 25, 2021
sector_ico_Health_trans Human Health
A chemo-affinity toolkit for methylation proteomics...

Protein methylation is a post-translational modification process involving the addition of methyl groups to a region of the protein.  The process plays an important role in pr...

May 25, 2021
sector_ico_Health_trans Human Health
Integrating Pediatric Pharmacogenomic Testing into the Canadian Health...

Pharmacogenomics is the study of how an individual’s genes affect their ability to respond to medications (drugs). This project has developed and implemented pharmacogenomic ...

May 25, 2021
sector_ico_Health_trans Human Health
Centre for Epigenome Mapping Technologies...

This national partnership with CIHR aims to support leading edge research on the role of DNA and environment interactions in human health and disease. Epigenetics is a field that i...

May 25, 2021
sector_ico_Health_trans Human Health
An Epigenomic Data Coordination Centre for Canada...

This national partnership with the Canadian Institutes of Health Research (CIHR) aims to support leading edge research on the role of DNA and environment interactions in human heal...

May 25, 2021
sector_ico_Health_trans Human Health
Preclincal development of a disease modifying small molecule therapy f...

No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). The two pathological hallmarks of AD are protein aggregates deposited in the brain that ...

May 25, 2021
sector_ico_Environment_trans Environment
Synthetic Biology Solutions for Detoxification of Oil Sands Process Af...

Oil sands mining industry generates large volumes of Oil Sand Process-affected Water (OSPW) consisting of persistent organic pollutants, such as Naphthenic Acids (NA). Treatment of...

May 25, 2021
sector_ico_Health_trans Human Health
PEGASUS-2 – PErsonalized Genomics for prenatal Abnormalities Scr...

The discovery that fetal DNA is present in the mother’s blood during pregnancy has led to the development of a genomics-based maternal blood test called NIPS (non-invasive pr...

May 25, 2021
sector_ico_Health_trans Human Health
Detection and Tracking of Carbapenemase-producing organisms (CPOs)...

Antibiotics are effective agents in the fight against microbial infections. However, their long term use, as well as the misuse, has led to rapid evolution and dissemination of ant...

May 25, 2021
sector_ico_Health_trans Human Health
Development, validation and worldwide dissemination of a standard and ...

More than a quarter of a million Canadians, including ~80,000 BC residents, are living with Hepatitis C and approximately 5,000 new infections occur annually across Canada. Chronic...

May 25, 2021
sector_ico_Health_trans Human Health
Viral and Human Genetic Predictors of Response to HIV Therapies...

The HIV drug "cocktail" has transformed AIDS from a fatal disease to a manageable condition. Unfortunately, HIV can become resistant to these drugs, leading to the development of f...

May 25, 2021
sector_ico_Health_trans Human Health
Automated Tumor Pathology...

To use genomics to aid in cancer treatment, a normal sample of the patients DNA is compared to the DNA from the cancerous tumour. This is&nb...

May 25, 2021
sector_ico_Health_trans Human Health
Improving Diagnosis and Treatment of Catecholaminergic Polymorphic Ven...

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited condition characterized by abnormal heartbeat (arrhythmia) resulting in sudden cardiac death (SCD) for ...

May 25, 2021
sector_ico_Environment_trans Environment
Development and Validation of Environmental DNA (eDNA) methods; Case S...

There is an increasing need to assess and monitor the impact of human activities on biodiversity. The environmental consulting industry in BC has an estimated $2 billion annua...

May 25, 2021
sector_ico_Environment_trans Environment
Long-term impacts of biosolids on soil microbial communities during mi...

Although biosolids have been used in BC mine reclamation for over 20 years, recent concerns have called into question their application. In 2015, the BC Ministry of Environment man...

May 25, 2021
sector_ico_Health_trans Human Health
Epigenetic Modifications Regulating Hepatocellular Carcinoma and Hepat...

There are over 100 types of liver disease and left untreated, these diseases can develop into liver cirrhosis and potentially into hepatocellular carcinoma (HCC). Thousands of Cana...

May 25, 2021
sector_ico_Health_trans Human Health
Epigenetic mechanisms for the development of asthma...

Asthma is a common chronic disorder that affects both children and adults and causes decreased quality of life for those who suffer from the illness and for their families. Asthma ...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
iMALDI-based Assays for Protein Activity to Improve Patient Selection ...

Research is discovering that cancer is not the monolithic disease it was once thought to be. In fact, most cancer types have many sub-types, each with its own distin...

May 25, 2021
sector_ico_Fisheries_trans Fisheries and Aquaculture
Inventory and Assessment of Health Risk of Microbes in BC (Phase 2b)...

Over 90% of juvenile salmon migrating from freshwater into the ocean will die before returning to freshwater to spawn, and disease may be a significant factor contributing to this ...

May 25, 2021
sector_ico_Environment_trans Environment
Natural Attenuation and Phytoremediation of Fracking Fluids...

Shale gas, the natural resource that feeds British Columbia’s Liquid Natural Gas strategy, is extracted using horizontal drilling and hydraulic fracturing (fracking). Frackin...

May 25, 2021
sector_ico_Health_trans Human Health
Modeling the influence of virus-microbiome relationships in type 1 dia...

Type 1 Diabetes (T1D) is a disease that typically manifests early, affecting approximately 1 in 500 children. As T1D develops, immune cells incorrectly identify the body’s ow...

May 25, 2021
sector_ico_Health_trans Human Health
Relationship between external and internal microbiomes in normal and c...

Nearly 1 in 20 Canadians suffer from Chronic Obstructive Pulmonary Disease (COPD), a type of chronic airway inflammation that can significantly restrict physical activity. COPD can...

May 25, 2021
sector_ico_Health_trans Human Health
Proteogenomics-Improved and -Guided Quantification Pipeline (PIGQpipe)...

Measuring proteins in biofluids such as urine or blood is critical for diagnosing, treating and monitoring disease in humans. Currently researchers and clinicians worldwide use mas...

May 25, 2021
sector_ico_Health_trans Human Health
Development and implementation of bioinformatic tools for HIV and HCV ...

In the developed world, where epidemics are well managed, it is becoming increasingly difficult to identify remaining pockets of ongoing HIV and Hepatitis C Virus (HCV) transmissio...

May 25, 2021
sector_ico_Health_trans Human Health
Machine learning methods to predict drug resistance in pathogenic bact...

Treatment options for people infected with antibiotic resistant bacteria today are limited and may become even more so over time. The risk of a post-antibiotic era, in which even m...

May 25, 2021
sector_ico_Health_trans Human Health
Illuminating the dark matter of the metabolome with convolutional neur...

The human body contains hundreds of thousands of naturally occurring chemicals, and is exposed to hundreds of thousands more during daily life. These chemicals, called metabolites,...

May 25, 2021
sector_ico_Health_trans Human Health
Automated analysis of big flow cytometry data...

Flow cytometry (FCM) is a technique used to detect and measure physical and chemical characteristics of a population of cells or particles.  It is commonly used for cancer dia...

May 25, 2021
sector_ico_Health_trans Human Health
Large Scale GE3LS Project- GenCOUNSEL- optimization of genetic counsel...

Genome-wide sequencing (GWS) is a powerful new genetic test that analyzes a person’s entire genetic make-up. While valuable, it can be problematic, by revealing disorders or ...

May 25, 2021
sector_ico_Health_trans Human Health
Genomic Epidemiology Application Ontology (GenEpiO)...

Infectious disease outbreaks have significant impacts on human health, agri-food production, animal health and the economy. Ineffective public health responses can result in outbre...

May 25, 2021
sector_ico_Health_trans Human Health
Reducing Stroke Burden with Hospital-Ready Biomarker Test for Rapid TI...

Every year, 50,000 Canadians have a stroke, making it the leading cause of disability in the country. However, an equal number of people suffer what are called transient ischemic a...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
Assessment of Mite Fertility – Development of a molecular-based ...

The two-spotted spider mite is a common pest in horticulture and to control these mites greenhouses often use chemical pesticides or another type of mite, Phytoseiulus persimilis, ...

May 25, 2021
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