Projects Archive - Page 7 of 12

Long-term impacts of biosolids on soil microbial communities during mi...

Although biosolids have been used in BC mine reclamation for over 20 years, recent concerns have called into question their application. In 2015, the BC Ministry of Environment man...

May 25, 2021

Epigenetic Modifications Regulating Hepatocellular Carcinoma and Hepat...

There are over 100 types of liver disease and left untreated, these diseases can develop into liver cirrhosis and potentially into hepatocellular carcinoma (HCC). Thousands of Cana...

May 25, 2021

Epigenetic mechanisms for the development of asthma...

Asthma is a common chronic disorder that affects both children and adults and causes decreased quality of life for those who suffer from the illness and for their families. Asthma ...

May 25, 2021

Data and Technology Human Health

iMALDI-based Assays for Protein Activity to Improve Patient Selection ...

Research is discovering that cancer is not the monolithic disease it was once thought to be. In fact, most cancer types have many sub-types, each with its own distin...

May 25, 2021

Inventory and Assessment of Health Risk of Microbes in BC (Phase 2b)...

Over 90% of juvenile salmon migrating from freshwater into the ocean will die before returning to freshwater to spawn, and disease may be a significant factor contributing to this ...

May 25, 2021

Natural Attenuation and Phytoremediation of Fracking Fluids...

Shale gas, the natural resource that feeds British Columbia’s Liquid Natural Gas strategy, is extracted using horizontal drilling and hydraulic fracturing (fracking). Frackin...

May 25, 2021

Modeling the influence of virus-microbiome relationships in type 1 dia...

Type 1 Diabetes (T1D) is a disease that typically manifests early, affecting approximately 1 in 500 children. As T1D develops, immune cells incorrectly identify the body’s ow...

May 25, 2021

Relationship between external and internal microbiomes in normal and c...

Nearly 1 in 20 Canadians suffer from Chronic Obstructive Pulmonary Disease (COPD), a type of chronic airway inflammation that can significantly restrict physical activity. COPD can...

May 25, 2021

Proteogenomics-Improved and -Guided Quantification Pipeline (PIGQpipe)...

Measuring proteins in biofluids such as urine or blood is critical for diagnosing, treating and monitoring disease in humans. Currently researchers and clinicians worldwide use mas...

May 25, 2021

Development and implementation of bioinformatic tools for HIV and HCV ...

In the developed world, where epidemics are well managed, it is becoming increasingly difficult to identify remaining pockets of ongoing HIV and Hepatitis C Virus (HCV) transmissio...

May 25, 2021

Machine learning methods to predict drug resistance in pathogenic bact...

Treatment options for people infected with antibiotic resistant bacteria today are limited and may become even more so over time. The risk of a post-antibiotic era, in which even m...

May 25, 2021

Illuminating the dark matter of the metabolome with convolutional neur...

The human body contains hundreds of thousands of naturally occurring chemicals, and is exposed to hundreds of thousands more during daily life. These chemicals, called metabolites,...

May 25, 2021

Automated analysis of big flow cytometry data...

Flow cytometry (FCM) is a technique used to detect and measure physical and chemical characteristics of a population of cells or particles. It is commonly used for cancer dia...

May 25, 2021

Large Scale GE3LS Project- GenCOUNSEL- optimization of genetic counsel...

Genome-wide sequencing (GWS) is a powerful new genetic test that analyzes a person’s entire genetic make-up. While valuable, it can be problematic, by revealing disorders or ...

May 25, 2021

Genomic Epidemiology Application Ontology (GenEpiO)...

Infectious disease outbreaks have significant impacts on human health, agri-food production, animal health and the economy. Ineffective public health responses can result in outbre...

May 25, 2021

Reducing Stroke Burden with Hospital-Ready Biomarker Test for Rapid TI...

Every year, 50,000 Canadians have a stroke, making it the leading cause of disability in the country. However, an equal number of people suffer what are called transient ischemic a...

May 25, 2021

Assessment of Mite Fertility – Development of a molecular-based ...

The two-spotted spider mite is a common pest in horticulture and to control these mites greenhouses often use chemical pesticides or another type of mite, Phytoseiulus persimilis, ...

May 25, 2021

A Syst-OMICS approach to ensuring food safety and reducing the economi...

It used to be that poultry was the usual suspect in cases of Salmonella poisoning. Today, however, most outbreaks of the illness come from fruit and vegetables, which become infect...

May 25, 2021

Poplar and cereal rust comparative genomics- identification of pathoge...

"Rusts" are a group of fungi that attack and damage plants and trees, costing the international agriculture and forestry sectors billions annually in lost revenue, with an estimate...

May 25, 2021

Building the Genomics Toolbox for Lavenders...

The project aimed to identify traits that could assist lavender farmers to improve yield and quality of the resulting essential oils thereby strengthening the industry in the provi...

May 25, 2021

Energy

Optimizing Hydrolytic Enzymes and Lignocellulosic substrates toward ma...

Using the excess beetle-killed pine as a source of fermentable sugars, the researchers used genomics to determine the most efficient methods to liberate fermentable sugars from the...

May 25, 2021

Personalized Treatment of Lymphoid Cancer- British Columbia as Model P...

Lymphoid cancers are often treated by a one-size-fits most approach. However, research has shown that genomic sequencing can decode the genetic instructions in both normal an...

May 25, 2021

Antibody Therapeutics for Duchenne Muscular Dystrophy...

Duchenne Muscular Dystrophy (DMD) is the most prevalent genetic disorder in the world, affecting 1 in 3500 males in Canada. People with DMD have a mutation in a gene that makes dys...

May 25, 2021

SMAC- Sharing Mycobacterial Analytic Capacity...

Although one-third of the world’s population is infected with Mycobacterium tuberculosis, the disease garners relatively little attention, as it is predominantly a disease of...

May 25, 2021

PEGASUS – Personalized Genomics for prenatal Aneuploidy Screenin...

Each year, 450,000 Canadian women become pregnant and, as a result of prenatal screening for Down syndrome, ~10,000 of them will have an amniocentesis; Of those tested, 315 will be...

May 25, 2021

Genomic and Outcomes Databank for Pharmacogenomic and Implementation S...

Adverse drug reactions (ADRs) are a major problem in modern medicine, leading to withdrawal of treatment, non-compliance with medication, permanent disability and death. This is pa...

May 25, 2021

Big Data Collaborative Networks: The Role of Communication in the Deve...

Big data genomics is becoming a disruptive technology that is impacting a range of industries in Canada. Technological innovations have made it easier to create and manage big data...

May 25, 2021

Childhood Asthma and the Microbiome – Precision Health for Life:...

Asthma is the most common chronic disease of childhood, affecting one in seven Canadian children (and more than three million Canadians of all ages). It is the most common reason f...

May 25, 2021

Deciphering the genome biology of relapsed lymphoid cancers to improve...

Lymphoid cancers, which start in the immune system and include Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, lymphocytic, and lymphoblastic leukemia, are the fifth-mos...

May 25, 2021

Care4Rare Canada- Harnessing multi-omics to deliver innovative diagnos...

There are more than 7,000 rare diseases in Canada, together having a devastating impact on some one million Canadians and their families. Two-thirds of the diseases cause significa...

May 25, 2021

Automation of the Clinical Bioinformatics Pipeline at the Centre for C...

Centre for Clinical Genomics (CCG), located at the BC Cancer Agency, pioneers in providing high-throughput next-generation sequencing (NGS) assays for cancer as well as non-maligna...

May 25, 2021

New bioinformatics for new sequencing technologies: Genome characteriz...

Over the last decade, technology advances have made DNA sequencing a routine and cost- effective method in many fields of life sciences research. The dominant technology toda...

May 25, 2021

Silent Genomes- Reducing health care disparities and improving diagnos...

In Canada, genomic sequencing to diagnose genetic conditions is a common practice across many medical specialties, including, but not limited to, clinical genetics, cardiology, imm...

May 25, 2021

Northern Biobank Initiative: Phase 2...

The Northern Biobank Initiative Phase 2 is the first biobank of its kind in British Columbia. It will enable Northern B.C. to better contribute to large-scale provincial and nation...

May 25, 2021

Droplet In-Vitro transcription/translation Enzyme IdenTification (DIVE...

Today, the “bioeconomy” is termed as the sustainable use of renewable resources throughout related productive sectors. The “knowledge based bio-economy” (KB...

May 25, 2021

Protist Metabolome Screening (Promise)...

Marine eukaryotic protists such as red algae are an abundant reservoir of metabolic pathways with biotechnology applications. There are promising new therapeutics such as anti-vira...

May 25, 2021

Advanced Marine Biotechnology toolbox for accessing the uncultivated m...

Microorganisms in the marine environment represent a largely untapped source of valuable biomolecules with commercial potential. Historically, scientists could only sequence lab-gr...

May 25, 2021

Development of an automated coring and nucleic acids extraction platfo...

The Provincial Health Services Authority (PHSA) is expanding clinical genomic testing to strengthen its efforts to be a leader in the use of next generation sequencing in cancer ca...

May 25, 2021

iTARGET – individualized Treatments for Autism Recovery using Ge...

Autism Spectrum Disorder (ASD) is defined by challenges with communication, social reciprocity, and behaviour. ASD is the most common childhood neurodevelopmental disorder and is i...

May 25, 2021

Clinical Implementation and Outcomes Evaluation of Blood-Based Biomark...

Chronic Obstructive Pulmonary Disease (COPD) damages the airways inside of our lungs, making it difficult to breathe. Patients suffer "lung attacks", characterized by coughing, bre...

May 25, 2021

Divseek Canada: Harnessing Genomics to Accelerate Crop Improvement in ...

Rapid population growth, a changing climate, and increasing constraints on land, water, and fertilizer threaten global food security. As a nation Canada must dramatically expand ag...

May 25, 2021

Validation of a next generation-based method for virus/viroid detectio...

High quality tree fruit production requires plants free of harmful pests and diseases. A statistical overview of the Canadian fruit industry by Agriculture and Agri-Food Canada, es...

May 25, 2021

Forestry

Spruce-Up – Advanced spruce genomics for productive and resilien...

Spruce trees make up 53% of Canada's forested area and contribute significantly to the $19.5 billion (2021) forestry industry. Breeding programs in BC and Quebec have been prov...

May 25, 2021

Adaptive capacities of microbiomes converting wastewatergrown microalg...

Municipal wastewater treatment is a major energy-consuming process that emits substantial greenhouse and is the largest source of nutrient-based pollution into Canada’s clean...

May 25, 2021

Forestry

Resilient Forests (RES-FOR) – Climate, Pests & Policy...

The forest industry generated $28 billion in exports and added $19.8 billion to the GDP in 2013. In Alberta alone, 50 communities are dependent on the forest industry for 13,000 di...

May 25, 2021

Sustaining freshwater recreational fisheries in a changing environment...

Recreational fishing is a treasured pastime, contributing more than $8 billion to the Canadian economy. Rainbow trout are a cornerstone of recreational fishing, but wild population...

May 25, 2021

Epigenetic adaptations of plants to climate change...

The world’s climate is warming at an unprecedented rate. Understanding how, and over what time frame, plants can adapt to warmer temperatures is a fundamental first step towa...

May 25, 2021

Forestry

Genomic differentiation among Northern Goshawks of coastal BC...

The Northern Goshawk (Accipiter gentilis) is a large, sturdy hawk that inhabits the Northern Hemisphere. British Columbia is home to two subspecies –coastal (A.g.laingi) and ...

May 25, 2021