Projects Archive - Page 7 of 12 - Genome BC

A Syst-OMICS approach to ensuring food safety and reducing the economi...

It used to be that poultry was the usual suspect in cases of Salmonella poisoning. Today, however, most outbreaks of the illness come from fruit and vegetables, which become infect...

May 25, 2021

Poplar and cereal rust comparative genomics- identification of pathoge...

"Rusts" are a group of fungi that attack and damage plants and trees, costing the international agriculture and forestry sectors billions annually in lost revenue, with an estimate...

May 25, 2021

Building the Genomics Toolbox for Lavenders...

The project aimed to identify traits that could assist lavender farmers to improve yield and quality of the resulting essential oils thereby strengthening the industry in the provi...

May 25, 2021

Optimizing Hydrolytic Enzymes and Lignocellulosic substrates toward ma...

Using the excess beetle-killed pine as a source of fermentable sugars, the researchers used genomics to determine the most efficient methods to liberate fermentable sugars from the...

May 25, 2021

Personalized Treatment of Lymphoid Cancer- British Columbia as Model P...

Lymphoid cancers are often treated by a one-size-fits most approach. However, research has shown that genomic sequencing can decode the genetic instructions in both normal an...

May 25, 2021

Antibody Therapeutics for Duchenne Muscular Dystrophy...

Duchenne Muscular Dystrophy (DMD) is the most prevalent genetic disorder in the world, affecting 1 in 3500 males in Canada. People with DMD have a mutation in a gene that makes dys...

May 25, 2021

SMAC- Sharing Mycobacterial Analytic Capacity...

Although one-third of the world’s population is infected with Mycobacterium tuberculosis, the disease garners relatively little attention, as it is predominantly a disease of...

May 25, 2021

PEGASUS – Personalized Genomics for prenatal Aneuploidy Screenin...

Each year, 450,000 Canadian women become pregnant and, as a result of prenatal screening for Down syndrome, ~10,000 of them will have an amniocentesis; Of those tested, 315 will be...

May 25, 2021

Genomic and Outcomes Databank for Pharmacogenomic and Implementation S...

Adverse drug reactions (ADRs) are a major problem in modern medicine, leading to withdrawal of treatment, non-compliance with medication, permanent disability and death. This is pa...

May 25, 2021

Big Data Collaborative Networks: The Role of Communication in the Deve...

Big data genomics is becoming a disruptive technology that is impacting a range of industries in Canada. Technological innovations have made it easier to create and manage big data...

May 25, 2021

Childhood Asthma and the Microbiome – Precision Health for Life:...

Asthma is the most common chronic disease of childhood, affecting one in seven Canadian children (and more than three million Canadians of all ages). It is the most common reason f...

May 25, 2021

Deciphering the genome biology of relapsed lymphoid cancers to improve...

Lymphoid cancers, which start in the immune system and include Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, lymphocytic, and lymphoblastic leukemia, are the fifth-mos...

May 25, 2021

Care4Rare Canada- Harnessing multi-omics to deliver innovative diagnos...

There are more than 7,000 rare diseases in Canada, together having a devastating impact on some one million Canadians and their families. Two-thirds of the diseases cause significa...

May 25, 2021

Automation of the Clinical Bioinformatics Pipeline at the Centre for C...

Centre for Clinical Genomics (CCG), located at the BC Cancer Agency, pioneers in providing high-throughput next-generation sequencing (NGS) assays for cancer as well as non-maligna...

May 25, 2021

New bioinformatics for new sequencing technologies: Genome characteriz...

Over the last decade, technology advances have made DNA sequencing a routine and cost- effective method in many fields of life sciences research. The dominant technology toda...

May 25, 2021

Silent Genomes- Reducing health care disparities and improving diagnos...

In Canada, genomic sequencing to diagnose genetic conditions is a common practice across many medical specialties, including, but not limited to, clinical genetics, cardiology, imm...

May 25, 2021

Northern Biobank Initiative: Phase 2...

The Northern Biobank Initiative Phase 2 is the first biobank of its kind in British Columbia. It will enable Northern B.C. to better contribute to large-scale provincial and nation...

May 25, 2021

Fisheries and Aquaculture

Droplet In-Vitro transcription/translation Enzyme IdenTification (DIVE...

Today, the “bioeconomy” is termed as the sustainable use of renewable resources throughout related productive sectors. The “knowledge based bio-economy” (KB...

May 25, 2021

Fisheries and Aquaculture

Protist Metabolome Screening (Promise)...

Marine eukaryotic protists such as red algae are an abundant reservoir of metabolic pathways with biotechnology applications. There are promising new therapeutics such as anti-vira...

May 25, 2021

Fisheries and Aquaculture

Advanced Marine Biotechnology toolbox for accessing the uncultivated m...

Microorganisms in the marine environment represent a largely untapped source of valuable biomolecules with commercial potential. Historically, scientists could only sequence lab-gr...

May 25, 2021

Development of an automated coring and nucleic acids extraction platfo...

The Provincial Health Services Authority (PHSA) is expanding clinical genomic testing to strengthen its efforts to be a leader in the use of next generation sequencing in cancer ca...

May 25, 2021

iTARGET – individualized Treatments for Autism Recovery using Ge...

Autism Spectrum Disorder (ASD) is defined by challenges with communication, social reciprocity, and behaviour. ASD is the most common childhood neurodevelopmental disorder and is i...

May 25, 2021

Clinical Implementation and Outcomes Evaluation of Blood-Based Biomark...

Chronic Obstructive Pulmonary Disease (COPD) damages the airways inside of our lungs, making it difficult to breathe. Patients suffer "lung attacks", characterized by coughing, bre...

May 25, 2021

Divseek Canada: Harnessing Genomics to Accelerate Crop Improvement in ...

Rapid population growth, a changing climate, and increasing constraints on land, water, and fertilizer threaten global food security. As a nation Canada must dramatically expand ag...

May 25, 2021

Validation of a next generation-based method for virus/viroid detectio...

High quality tree fruit production requires plants free of harmful pests and diseases. A statistical overview of the Canadian fruit industry by Agriculture and Agri-Food Canada, es...

May 25, 2021

Spruce-Up – Advanced spruce genomics for productive and resilien...

Spruce trees make up 53% of Canada's forested area and contribute significantly to the $19.5 billion (2021) forestry industry. Breeding programs in BC and Quebec have been prov...

May 25, 2021

Adaptive capacities of microbiomes converting wastewatergrown microalg...

Municipal wastewater treatment is a major energy-consuming process that emits substantial greenhouse and is the largest source of nutrient-based pollution into Canada’s clean...

May 25, 2021

Resilient Forests (RES-FOR) – Climate, Pests & Policy...

The forest industry generated $28 billion in exports and added $19.8 billion to the GDP in 2013. In Alberta alone, 50 communities are dependent on the forest industry for 13,000 di...

May 25, 2021

Fisheries and Aquaculture

Sustaining freshwater recreational fisheries in a changing environment...

Recreational fishing is a treasured pastime, contributing more than $8 billion to the Canadian economy. Rainbow trout are a cornerstone of recreational fishing, but wild population...

May 25, 2021

Epigenetic adaptations of plants to climate change...

The world’s climate is warming at an unprecedented rate. Understanding how, and over what time frame, plants can adapt to warmer temperatures is a fundamental first step towa...

May 25, 2021

Genomic differentiation among Northern Goshawks of coastal BC...

The Northern Goshawk (Accipiter gentilis) is a large, sturdy hawk that inhabits the Northern Hemisphere. British Columbia is home to two subspecies –coastal (A.g.laingi) and ...

May 25, 2021

Transcriptome and metabolite profiling of crop-pest interactions under...

Currently, greater than 20% of net plant productivity is removed annually by insect herbivores in fruit and vegetable cropping systems. This loss could be exacerbated by elevated C...

May 25, 2021

SYNBIOMICS: Functional genomics and techno-economic models for advance...

The SYNBIOMICS project aimed to advance sustainable bioproduct synthesis by reconstructing and upgrading abundant but underutilized woody biomass—cellulose, hemicellulose, an...

May 25, 2021

Spruce tree and spruce beetle genomics for response to a growing infes...

The recent spruce beetle outbreak in BC is larger than any previously recorded outbreak and has the potential to change forest ecosystems in BC. Increased spruce beetle activity ca...

May 25, 2021

Cedar Enhanced Durability and Resistance (CEDaR): Sustainability of Ca...

Canada’s $1.1B iconic western redcedar (WRC) export industry is facing a precipitous decline, as the durable and aesthetically appealing timber supply moves from old growth t...

May 25, 2021

CoAdapTree – Healthy trees for future climates...

This project aims to develop better reforestation options for high-value tree species such as Douglas fir and lodgepole pine, as well as western larch and jack pine trees. Genomic ...

May 25, 2021

BioSurveillance of Alien Forest Enemies (bioSAFE)...

Forests are a crucial part of Canada’s cultural, social and economic fabric. However, invasive alien species and diseases threaten our forests and cause potentially irreversi...

May 25, 2021

Data and Technology

The Metabolomics Innovation Centre (TMIC)...

The Metabolomics Innovation Centre (TMIC) was launched in 2011 as a Genome Canada Science and Technology Innovation Centre. TMIC now serves as Canada’s national metabolomics ...

May 25, 2021

Targeting the Synaptic Pathway in Neurodevelopmental and Psychiatric D...

Autism and schizophrenia affect over 1% of the population, and each has strong genetic associations with 60-90% heritability among twins. Recent research identified mutations in a ...

May 25, 2021

Locally produced brain insulin in memory and Alzheimer’s disease...

It is clear from population-level studies that there are important links between Alzheimer’s disease and obesity, altered fat metabolism, diabetes and insulin. The team demon...

May 25, 2021

Prevention of Healthcare Associated Infections in Bone Marrow Transpla...

Healthcare-associated infections (HAI) continue to burden patients and healthcare systems worldwide. Current environmental surveillance programs rely on culture-based methods to de...

May 25, 2021

Canadian ‘Rare Diseases: Models & Mechanisms’ Network...

Mutations in the human genome can cause rare diseases. In Canada, one in 12 people are affected by a rare disease — about two-thirds of them are children. Identifyin...

May 25, 2021

Reimagining genome browsing for the era of single cell genomics...

Human tumours develop through the accumulation of mutations in their DNA. Individual cells within a tumour can acquire different mutations, which may respond differently to therapy...

May 25, 2021

Protecting Canada’s Forests against Invasive Alien Species by Ne...

In 2016, the forest industry contributed over $23 billion to Canada’s nominal Gross Domestic Product. As one of the most important manufacturing sectors, forestry made ...

May 25, 2021

Canadian National Transplant Research Program: Increasing Donation an...

Organ and bone marrow transplants are well-established treatments for patients with incurable medical conditions. However, major gaps and obstacles prevent transplantation from bei...

May 25, 2021

Development of Novel Biomarker Blood Tests for COPD...

Chronic Obstructive Pulmonary Disease (COPD) is a chronic, progressive disease that results in damaged lung airways, making it difficult to breathe. Patients suffer “lu...

May 25, 2021

Immunogenomics Core...

The BC Cancer Agency's Cancer Immunotherapy Program aims to use genomic and related technologies to develop precise and potent immunotherapeutic strategies for cancer. To ...

May 25, 2021

Targeting Amyloid Propagation in Alzheimer Disease: Structures, Immuno...

Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the primary cause of brain cell death in Alzheimer’s disease. The ...

May 25, 2021

Propagated protein misfolding of SOD1 in ALS: Exemplar for Neurodegene...

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive fatal disease that affects the nerve cells responsible for muscle movement. 30,000 individ...

May 25, 2021

Reference Genome Sequences for Apple and Sweet Cherry Licensing Enforc...

BC's interior tree fruit industry generates $130 million in wholesale revenue, contributes $900 million in economic activity, and directly employs 1,500 people annually. Ninety-fiv...

May 25, 2021