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  • YEAR
    • 2017
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sector_ico_Health_trans Human Health
Pathogenomics of Innate Immunity (PI2)...

Despite being exposed to tens of thousands of potentially pathogenic microbes daily, we rarely succumb to infection, primarily due to our innate immune system. This ‘innate-i...

May 25, 2021
sector_ico_Health_trans Human Health
Dissecting Gene Expression Networks in Mammalian Organogenesis...

The mouse has been established as an important model organism in biomedical studies due to the high degree of genetic homology between mouse and humans plus the powerful ability to...

May 25, 2021
sector_ico_Health_trans Human Health
High Resolution Analysis of Follicular Lymphoma Genomes...

Follicular lymphoma (FL), the most common type of lymphoma, is a cancer of the cells of the immune system. Follicular lymphoma is associated with a specific genome rearrangement wh...

May 25, 2021
sector_ico_Fisheries_trans Fisheries and Aquaculture
Building a GE3LS Architecture (GE3LS ARC)...

An objective of Genome Canada is to ‘ensure leadership in ethical, environmental, economic, legal and social issues (GE³LS) related to genomics and proteomics research.&...

May 25, 2021
sector_ico_Forestry_trans Forestry
Conifer Forest Health Genomics...

Spruce is the dominant conifer species in Canada and is the most important tree of the Canadian forest industry. This project aimed to identify the genetic traits of spruce trees t...

May 25, 2021
sector_ico_Health_trans Human Health
Functional Genomics for Emerging Infectious Diseases (PREPARE) Project...

As a global community, we are constantly fighting infectious diseases that threaten health and reduce productivity. Emerging infectious diseases (EIDs) include drug resistant staph...

May 25, 2021
sector_ico_Health_trans Human Health
Efficient Identification and Cloning of Single Gene Deletions in the N...

The nematode C. elegans is a powerful research tool to investigate fundamental questions about biology. It was the first multicellular organism for which a complete DNA sequence wa...

May 25, 2021
sector_ico_Health_trans Human Health
Better Biomarkers of Acute and Chronic Allograft Rejection...

After transplantation of a heart, kidney, or liver, the immune system may attack the foreign organ so patients are treated with immunosuppressant medication to prevent rejection. H...

May 25, 2021
sector_ico_Health_trans Human Health
Genomic Tools for Diagnosis and Evaluation of Mental Retardation...

Mental retardation, which is usually defined as an IQ score below 70, occurs in approximately 1% of the population. It is the most frequent cause of severe life-long disability in ...

May 25, 2021
sector_ico_Health_trans Human Health
Application of Pharmacogenomics for Rational Chemotherapy of Lung Canc...

This lung cancer project has been instrumental in determining genetic markers that could inform clinicians of the potential success (or failure) of a particular treatment before ch...

May 25, 2021
sector_ico_Health_trans Human Health
Innovative Genomic Applications to Develop Clinical Biomarkers and Nov...

Iron is essential to bind oxygen and transport electrons for all living organisms, but iron overload and maldistribution have been implicated in the etiology of many disorders, inc...

May 25, 2021
sector_ico_Health_trans Human Health
Development and Validation of Comparative Genomic Hybridization Arrays...

Cancer research involves examining genetic changes associated with cancer development and progression. This project has developed and evaluated tiling resolution whole genome array...

May 25, 2021
sector_ico_Health_trans Human Health
Genotype Specific Approaches to Therapy in Childhood (GATC)...

Adverse reactions to approved prescription drugs are a major health concern and children are particularly vulnerable. These adverse drug reactions (ADRs) cause 10,000-22,000 deaths...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
Bovine Genome Sequencing Program- Full-length cDNA Sequencing...

The bovine genome is similar in size to the genomes of humans, with approximately 3 billion base pairs and approximately 25,000 genes. Sequences for full-length cDNA clones derived...

May 25, 2021
sector_ico_Agrifood_trans Agrifood
GrapeGen- A Genomic Approach to the Identification of the Genetic and ...

This research project investigated the grape ripening process at a molecular level and the changes in that process in response to various environmental conditions. Grapevine (Vitis...

May 25, 2021
sector_ico_Health_trans Human Health
Functional Pathogenomics of Mucosal Immunity...

Despite being exposed to tens of thousands of potentially pathogenic microbes daily, we rarely succumb to infection, primarily due to our innate immune system. This ‘innate-i...

May 25, 2021
sector_ico_Health_trans Human Health
Expression Profiles of Cells and Tissues in C. elegans...

The nematode C. elegans is a powerful research tool to investigate fundamental questions about biology. It was the first multicellular organism for which a complete DNA sequence wa...

May 25, 2021
Data and Technology
Sequencing & Mapping...

Sequencing and Mapping is the largest platform technology to be supported by Genome BC. It has been created through a partnership between Genome BC and the Genome Sciences Centre (...

May 25, 2021
sector_ico_Forestry_trans Forestry
Treenomix- Mechanisms of Wood Formation and Pest Resistance in Forest ...

Sustainable forestry in Canada will benefit from a genomic understanding of trees. The researchers looked at the spruce and poplar species, plus an applicable and biologically well...

May 25, 2021
sector_ico_Health_trans Human Health
Brain Channelopathies – Target Validation and Novel Therapeutic ...

This project expected to provide new insights into how particular genetic alterations affect calcium channel properties resulting in the disruption of normal brain functions, and c...

May 25, 2021
sector_ico_Health_trans Human Health
Somatostatin 2 Receptor (SSTR2) Antagonists for the Prevention of Hypo...

The primary limitation to effective insulin therapy to improve blood sugar control in Type 1 diabetes (T1D) is the risk of hypoglycemia, also known as low blood sugar. Hypoglycemia...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Centre for Epigenome Mapping Technologies (CEMT) Phase 2...

The term epigenome refers to chemical modifications of DNA and proteins that control the structure and regulation of the "genome," referring to all the DNA within our cel...

May 25, 2021
sector_ico_Health_trans Human Health
Discovery and development of novel anti-bacterial drugs...

The primary objective of this project is to confirm the antibacterial activity of compound 043 and 049 analogs in the presence and absence of a synergistic antibiotic and esta...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Development and commercialization of standardized reagents and guideli...

Aside from the overall time it usually takes to develop a drug before it can be introduced into the market - usually > 10 years - two major challenges to developing a new drug a...

May 25, 2021
sector_ico_Health_trans Human Health
Synthetic Lethality – Targeting FEN1 for more selective cancer t...

This project proposes to screen additional CDRD chemical libraries in order to identify a greater number of unique compounds that inhibit FEN1 at low micromolar potency. In paralle...

May 25, 2021
sector_ico_Health_trans Human Health
Canadian Humans and the Microbiome Program...

As many as 1,000 different species of bacteria make their homes inside or on humans. Yet, we have had little understanding of their role in human health and disease. New scientific...

May 25, 2021
Data and Technology
Microarray Platform...

Microarray technology provides a fast and economical method for expression analysis of tens of thousands of genes concurrently. The differences in gene expression between discreet ...

May 25, 2021
Data and Technology
Microarray Facility...

Microarray technology provides a fast and economical method for expression analysis of tens of thousands of genes concurrently. The differences in gene expression between discreet ...

May 25, 2021
Data and Technology
Genomics Technology Platform...

The bioinformatics platform at Canada's Michael Smith Genome Sciences Centre (GSC) is at the forefront of genomics research and collaboration. It has made seminal contributions to ...

May 25, 2021
sector_ico_Health_trans Human Health
Inhibitors of New Delhi Metallo-B-Lactamase 1...

Antibiotic resistance in pathogenic microoganisms is now regarded to be a major threat to human health. One of the most worrying examples of this problem is the rapid emergence and...

May 25, 2021
sector_ico_Health_trans Human Health
Inhibitors of the CBX7-H3K27me3 epigenetic interaction for castration ...

Prostate cancer is the most commonly diagnosed non-skin cancer in Canadian men, with an estimated 26,500 new cases in 2012. Current treatment options for castration-resistant prost...

May 25, 2021
sector_ico_Health_trans Human Health
High-throughput Screening in C. elegans for Anthelmintics to treat Fil...

Onchocerciasis (river blindness) and lymphatic filiariasis (elephantiasis) are the most serious human health problems caused by parasitic worms. At least 25 million people are infe...

May 25, 2021
sector_ico_Health_trans Human Health
Commercial Development of Lipid Nanoparticle Reagents for Functional G...

There is a growing demand for new innovative technologies for use in "hard-to-transfect" cells, such as primary cells and stem cells. Transfection tools are used routinely by 51% o...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Barracuda Technology Port and Application Expansion...

The gel size selection method for next generation sequencing (NGS) has remained a largely manual process and thus highly expensive. The aim of this project was to help Coastal Geno...

May 25, 2021
sector_ico_Health_trans Human Health
Identification of Modulators of the Mesenchymal Progenitor Cell Phenot...

This project's goal is to screen 175,000 compounds to identify agents that promote mesenchymal progenitor (MP) quiescence using increased Hic1 expression as a surrogate marker. 60 ...

May 25, 2021
sector_ico_Health_trans Human Health
One-Step 18F-Labeling – Development of Clinically Useful PET Ima...

Positron-emission tomography (PET) is a nuclear medicine functional imaging technique used to observe metabolic processes in the body as an aid to the diagnosis of disease. A PET s...

May 25, 2021
sector_ico_Health_trans Human Health
Research and Development of a Novel Treatment for Hypertrophic Scarrin...

Hypertrophic scar formation arising from burn injuries, traumatic injuries, and surgical procedures is a major clinical problem in the developing and industrialized worlds. The cos...

May 25, 2021
sector_ico_Health_trans Human Health
Xigris Companion Diagnostic (XCD)...

Severe sepsis affects >1.5 million patients annually in Canada, the US, and Europe with mortality rates of 30% to 70% for septic shock. Xigris, (sold by Eli Lilly) is currently ...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
High-throughput Bacterial Transcriptome Mapping- A Case Study...

These projects investigated bacterial genomics with the intent of developing new tools to uncover the mechanisms by which they can become more pathogenic. Genetic recombination is ...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Short Sequence Assembly and Finishing of Large Genomes...

The project team based in BC Genome Sciences Centre developed a computational tool named Trans-AbySS that is highly effective in identifying novel RNA molecules. The project team d...

May 25, 2021
sector_ico_Health_trans Human Health
Bioinformatics of Mammalian Gene Expression...

The project team based in BC Genome Sciences Centre developed a computational tool named Trans-AbySS that is highly effective in identifying novel RNA molecules. The project team d...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Development of Efficient Algorithms and Technologies for Structural Va...

The goal of this project was to develop a novel and efficient algorithms for managing, filtering and analyzing data generated by these platforms, both for main stream PCs as well a...

May 25, 2021
sector_ico_Health_trans Human Health
CAE/BC Biolibrary Project- Guidelines, Protocols and Policies...

Biobanks are centralized collections of human blood, tissue samples and other data, and are vital for health research as they serve the needs of researchers for access to high qual...

May 25, 2021
sector_ico_Health_trans Human Health
Novel Influenza Neuraminidase Inhibitors – Development of Orally...

More than one million people die of influenza every year, and another 1.3 billion more are infected, making this project of keen interest to government health regulatory authoritie...

May 25, 2021
Data and Technology sector_ico_Health_trans Human Health
Commercial development of short interfering RNA-lipid nanoparticles (s...

This project was a collaboration between UBC and Precision NanoSystems Inc. (PNI), a UBC spin-out company founded in 2010 based around microfluidic technology (the NanoAssemblr) th...

May 25, 2021
sector_ico_Health_trans Human Health
Anti-Influenza Therapeutics – Development of M2 Inhibitors...

The key interim milestone (analog with improved activity/PK) was not achieved. CDRD has decided to discontinue the project and not proceed with remaining tasks in the plan. The pro...

May 25, 2021
sector_ico_Health_trans Human Health
Development of a synergistic combination of two known drugs for mycoba...

Tuberculosis (TB) is the 2nd leading cause of death by infectious disease in adults worldwide and it is estimated that one third of the world’s population is infected with My...

May 25, 2021
sector_ico_Health_trans Human Health
Synthetic Platelets...

Platelets, or thrombocytes, are the first responders to vascular injury and are critical to stop bleeding. There is a huge demand for platelets for treatment of patients with bleed...

May 25, 2021
sector_ico_Health_trans Human Health
Therapeutic Strategies for Huntington’s Disease...

Huntington’s disease (HD) is a devastating neurodegenerative disorder that is characterized by onset of chorea and psychiatric disturbances usually in middle age, accompanied...

May 25, 2021
sector_ico_Health_trans Human Health
Development of TDP1 inhibitors for use in cancer therapy...

The all too common development of resistance to therapy is a major obstacle to successful cancer treatment. Therefore understanding the mechanisms by which tumours become insensiti...

May 25, 2021
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