Large Scale Applied Research Programs Archives

Environment

iTrackDNA: Non-Destructive Precision Genomics for Environmental Impact...

Canada is a natural resource exporting nation that values its biodiversity, clean water and distinctive ecosystems. This vast nation is at a critical juncture with competing intere...

April 01, 2022

Environment

The Canadian BioGenome Project...

A genome contains the genetic blueprint of life. Each species possesses a characteristic genome, shaped by millions of years of evolution, that makes it specifically adapted to its...

January 29, 2022

Agrifood

PeptAid – Antimicrobial Peptides To Replace Antibiotics in Farm ...

Antibiotics are not an uncommon input in animal husbandry. However, overuse of antibiotics has caused some bacteria to become resistant to these drugs, contributing to the crisis o...

May 25, 2021

Agrifood

Sustaining and securing Canada’s honey bees using ‘omic to...

Honey bees are a crucial part of Canadian agriculture, contributing at least $4.6 billion/y: they produce between eighty and ninety thousand tonnes of honey each year and thei...

May 25, 2021

Agrifood

BeeCSI: ‘omic tools for assessing bee health...

Honey bees are crucial to agriculture and contribute up to $5.5 billion annually to the Canadian economy by pollinating valuable Canadian crops. However, the health of honey bees h...

May 25, 2021

Agrifood

Integrating genomic approaches to improve dairy cattle resilience: A c...

Dairy is one of Canada's most important and dynamic industries. In 2015, the dairy sector contributed roughly $19.9 billion to Canada’s gross domestic product (GDP). This...

May 25, 2021

Human Health

Precision Medicine CanPREVENT AMR- Applying Precision Medicine Technol...

Transplantation is the treatment of choice for patients whose kidneys have failed, providing superior survival, better quality of life and lower health-care system costs (<$20,0...

May 25, 2021

Human Health

PEGASUS-2 – PErsonalized Genomics for prenatal Abnormalities Scr...

The discovery that fetal DNA is present in the mother’s blood during pregnancy has led to the development of a genomics-based maternal blood test called NIPS (non-invasive pr...

May 25, 2021

Human Health

Viral and Human Genetic Predictors of Response to HIV Therapies...

The HIV drug "cocktail" has transformed AIDS from a fatal disease to a manageable condition. Unfortunately, HIV can become resistant to these drugs, leading to the development of f...

May 25, 2021

Human Health

Large Scale GE3LS Project- GenCOUNSEL- optimization of genetic counsel...

Genome-wide sequencing (GWS) is a powerful new genetic test that analyzes a person’s entire genetic make-up. While valuable, it can be problematic, by revealing disorders or ...

May 25, 2021

Human Health

Reducing Stroke Burden with Hospital-Ready Biomarker Test for Rapid TI...

Every year, 50,000 Canadians have a stroke, making it the leading cause of disability in the country. However, an equal number of people suffer what are called transient ischemic a...

May 25, 2021

Agrifood

A Syst-OMICS approach to ensuring food safety and reducing the economi...

It used to be that poultry was the usual suspect in cases of Salmonella poisoning. Today, however, most outbreaks of the illness come from fruit and vegetables, which become infect...

May 25, 2021

Human Health

Personalized Treatment of Lymphoid Cancer- British Columbia as Model P...

Lymphoid cancers are often treated by a one-size-fits most approach. However, research has shown that genomic sequencing can decode the genetic instructions in both normal an...

May 25, 2021

Human Health

PEGASUS – Personalized Genomics for prenatal Aneuploidy Screenin...

Each year, 450,000 Canadian women become pregnant and, as a result of prenatal screening for Down syndrome, ~10,000 of them will have an amniocentesis; Of those tested, 315 will be...

May 25, 2021

Human Health

Genomic and Outcomes Databank for Pharmacogenomic and Implementation S...

Adverse drug reactions (ADRs) are a major problem in modern medicine, leading to withdrawal of treatment, non-compliance with medication, permanent disability and death. This is pa...

May 25, 2021

Human Health

Childhood Asthma and the Microbiome – Precision Health for Life:...

Asthma is the most common chronic disease of childhood, affecting one in seven Canadian children (and more than three million Canadians of all ages). It is the most common reason f...

May 25, 2021

Human Health

Deciphering the genome biology of relapsed lymphoid cancers to improve...

Lymphoid cancers, which start in the immune system and include Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, lymphocytic, and lymphoblastic leukemia, are the fifth-mos...

May 25, 2021

Human Health

Care4Rare Canada- Harnessing multi-omics to deliver innovative diagnos...

There are more than 7,000 rare diseases in Canada, together having a devastating impact on some one million Canadians and their families: two-thirds of the diseases cause significa...

May 25, 2021

Human Health

Silent Genomes- Reducing health care disparities and improving diagnos...

First Nations, Inuit and Métis’ populations, collectively known as the Indigenous Peoples’ of Canada, face strikingly similar health challenges with global Indig...

May 25, 2021

Human Health

Clinical Implementation and Outcomes Evaluation of Blood-Based Biomark...

Chronic Obstructive Pulmonary Disease (COPD) damages the airways inside of our lungs, making it difficult to breathe. Patients suffer "lung attacks", characterized by coughing, bre...

May 25, 2021

Forestry

Spruce-Up – Advanced spruce genomics for productive and resilien...

Spruce trees make up 53% of Canada's forested area and contribute significantly to the $19.5 billion (2021) forestry industry. Breeding programs in BC and Quebec have been prov...

May 25, 2021

Forestry

Resilient Forests (RES-FOR) – Climate, Pests & Policy...

The forest industry generated $28 billion in exports and added $19.8 billion to the GDP in 2013. In Alberta alone, 50 communities are dependent on the forest industry for 13,000 di...

May 25, 2021

Fisheries and Aquaculture

Sustaining freshwater recreational fisheries in a changing environment...

Recreational fishing is a treasured pastime, contributing more than $8 billion to the Canadian economy. Rainbow trout are a cornerstone of recreational fishing, but wild population...

May 25, 2021

Forestry

SYNBIOMICS: Functional genomics and techno-economic models for advance...

In a world that is requiring increasingly biological-based solutions to meet sustainably a growing need for materials, tree biomass remains one of the most abundant resources on ea...

May 25, 2021

Forestry

CoAdapTree – Healthy trees for future climates...

This project aims to develop better reforestation options for high-value tree species such as Douglas fir and lodgepole pine, as well as western larch and jack pine trees. Genomic ...

May 25, 2021

Forestry

BioSurveillance of Alien Forest Enemies (bioSAFE)...

Forests are a crucial part of Canada’s cultural, social and economic fabric. However, invasive alien species and diseases threaten our forests and cause potentially irreversi...

May 25, 2021

Human Health

IBD Genomic Medicine Consortium (iGenoMed)- translating genetic discov...

Inflammatory bowel disease (IBD) results from chronic inflammation in the digestive system. Canada has among the highest frequency of people with IBD in the world with over 250,000...

May 25, 2021

Fisheries and Aquaculture

Enhancing Production in Coho: Culture, Community, Catch (EPIC4)...

With 25% of the world's coastline and 16% of the world's freshwater, Canada is well-positioned to build a stronger and vibrant blue economy in an ecologicall...

May 25, 2021

Agrifood

Reverse Vaccinology Approach for the Prevention of Mycobacterial Disea...

Infectious diseases continue to be a leading cause of sickness and death in livestock and are of concern to human health due to their potential to be transferred to people. Vaccina...

May 25, 2021

Agrifood

Genomics of Abiotic Stress Resistance in Wild and Cultivated Sunflower...

Drought, flooding, salt and low nutrient levels negatively affect plant growth and lower crop productivity. These environmental stresses have the greatest impact on our highly adap...

May 25, 2021

Human Health

Orphan Diseases- Identifying Genes and Novel Therapeutics to Enhance T...

One in twelve Canadians suffers from an “Orphan Disease” (OD). These are diseases that have not been adopted by the pharmaceutical industry because they affect a small ...

May 25, 2021

Energy

POPCAN- Genetic improvement of poplar trees as a Canadian bioenergy fe...

The extensive use of fossil fuels is a key contributor to climate change. The Government of Canada mandated a five percent renewable fuel content in gasoline, however production is...

May 25, 2021

Agrifood

Next-generation Integrated Pest Management tools for beekeeping...

Bees play a major role in agriculture as pollinators of crops. Over the past few years, North American beekeepers have lost colonies at an alarming rate. This project aimed to deve...

May 25, 2021

Human Health

Stratifying and Targeting Pediatric Medulloblastoma Through Genomics...

Cancer is the leading cause of non-accidental death in Canadian children, and brain tumors (medulloblastoma) are the leading cause of pediatric cancer deaths. The aggressive treatm...

May 25, 2021

Environment

Applied Metagenomics of the Watershed Microbiome...

Canada's watersheds are important natural resources, providing drinking water as well as water for agricultural, industrial and recreational uses. Growing demands from industry and...

May 25, 2021

Forestry

Genomics-Based Forest Health Diagnostics and Monitoring...

Canada’s forests are increasingly under threat by pests and pathogens, resulting in annual losses of about $2 billion. The Tree Aggressors Identification using Genomic Approa...

May 25, 2021

Forestry

SMarTForest- Spruce Marker Technologies for Sustainable Forestry...

Forestry products contribute approximately $23.1 billion to Canada's GDP. The SMarTForest team developed genomic selection methods as tree breeding tools which provide accurate pre...

May 25, 2021

Forestry

Harnessing microbial diversity for sustainable use of forest biomass r...

In order to remain competitive, the Canada’s forest industry must develop both better forest management and extract forest biomass related products that are of value to custo...

May 25, 2021

Forestry

AdapTree- Assessing the adaptive portfolio of reforestation stocks for...

In BC and Alberta alone, ~150 million spruce and lodgepole pine trees are planted annually, however, climate change is threatening forest health by causing a mismatch between the n...

May 25, 2021

Agrifood

Value Addition to Genomics and GE3LS (VALGEN)...

Research in genomics progresses at a rapid pace, and drives innovation in key areas of economically important research. The VALGEN project was designed to understand and respond to...

May 25, 2021

Energy

Metagenomics for Greener Production and Extraction of Hydrocarbon Ener...

This project proposed to characterize whole genomes of bacterial communities that naturally live in environments from which we extract energy, such as oil sands and coal beds. ...

May 25, 2021

Energy

Synthetic Biosystems for the Production of High-Value Plant Metabolite...

The PhytoMetaSyn Project used massively parallel DNA sequencing to investigate the processes and biosynthetic pathways by which selected plant species produced high-value plant met...

May 25, 2021

Energy

Genomics of Sunflower...

Worldwide, sunflower oilseed crops are valued at about $20 billion annually and sunflower species are grown commercially on 22 million hectares around the globe, currently the worl...

May 25, 2021

Forestry

Genomics-Enhanced Forecasting Tools to Secure Canada’s Near-Term...

The mountain pine beetle outbreak has caused unprecedented damage to the Canadian forest industry. The current infestation has affected more than 18 million hectares of pine forest...

May 25, 2021

Agrifood

Grape and Wine Genomics...

The contribution of BC wine sales to provincial agri-business has grown significantly over the past decade. In 2011, the BC wine and grape industry contributed a total of $2.01Bill...

May 25, 2021