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sector_ico_Health_trans Human Health

Somatostatin 2 Receptor (SSTR2) Antagonists for the Prevention of Hypoglycemia

  • Project Leaders: Michael Riddell
  • Institutions: York University
  • Budget: $309907
  • Program/Competition: Other Programs
  • Genome Centre(s): Genome British Columbia
  • Fiscal Year: 2015
  • Status: Closed

The primary limitation to effective insulin therapy to improve blood sugar control in Type 1 diabetes (T1D) is the risk of hypoglycemia, also known as low blood sugar. Hypoglycemia is considered to be a medical emergency that requires a rapid response to prevent organ and brain damage. This project aims to create the first treatment to restore the body’s ability to counter-regulate insulin-induced hypoglycemia, which would result in better overall health outcomes in the long term for type 1 diabetic patients. The approach is to block somatostatin type 2 (SSTR2) receptors, which is expected to normalize the response of the pancreas to hypoglycemia. The main purpose of the work proposed is to demonstrate safety and efficacy of a candidate molecule to advance toward clinical trials.