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Short Sequence Assembly and Finishing of Large Genomes

  • Project Leaders: Inanc Birol, Steven Jones
  • Institutions: BC Cancer (Previously BC Cancer Agency (BCCA))
  • Budget: $190800
  • Program/Competition: Strategic Opportunities Fund
  • Genome Centre(s): Genome British Columbia
  • Status: Closed

The project team based in BC Genome Sciences Centre developed a computational tool named Trans-AbySS that is highly effective in identifying novel RNA molecules. The project team developed a method that could correctly reconstruct thousands of RNA sequences from short sequence reads generated by next generation sequencing technologies. Specifically, with Trans-ABySS, the team demonstrated that it can be used assemble to reconstruct (from millions of tiny segments) the total RNAs in a sample for non-Hodgkins lymphoma. In fact, the project team was able to detect known RNA mutations associated with this disease. The project team aims to apply this approach to survey a wider range of other cancer types.