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Prenatal Exposure to Wildfire Disasters and their Association with Early Childhood Health, Development, Epigenomics, and Inflammation

SIP036
  • Project Leaders: Michael Kobor
  • Institutions: University of British Columbia (UBC)
  • Budget: $499999
  • Program/Competition: Sector Innovation Program
  • Genome Centre(s): Genome British Columbia
  • Fiscal Year: 2024
  • Status: Active

Wildfires are becoming more frequent and severe in British Columbia and beyond due to climate change. These events are linked to serious risks to our respiratory health and can disproportionately affect vulnerable populations such as people who are pregnant and their unborn children.  

This study, led by Dr Michael Kobor, will examine the lasting health effects of prenatal wildfire exposure using advanced genetic techniques. This exploration of the association between prenatal wildfire exposure and respiratory outcomes after birth is the first of its kind and aims: 

  • to determine whether prenatal wildfire exposure can cause changes at the genetic level that increase children’s risk of respiratory issues and  

  • to provide a comprehensive understanding of the biological mechanisms linking prenatal wildfire exposure to respiratory health impacts such as asthma and allergies.  

With prior approval from parents, dried blood spots previously collected at birth and parent survey responses will be analyzed to explore this relationship.  

Determining whether prenatal wildfire exposure leads to negative respiratory health outcomes can ultimately help identify children at risk for developing respiratory and allergic conditions. By raising awareness of the health risks associated with prenatal wildfire exposure, the potential research findings may support the creation of new guidelines and recommendations for pregnant individuals, empower families and healthcare providers to take proactive steps to limit exposure, improve health outcomes, reduce related healthcare costs, and improve lives.