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Modeling and Therapeutic Targeting of the Clinical and Genetic Diversity of Glioblastoma (Therapeutic Targeting of GBM)

C34GBM
  • Project Leaders: Gregory Cairncross, David Kaplan, Marco Marra, Samuel Weiss, Stephen Robbins, Warren Mason
  • Institutions: University of British Columbia (UBC)
  • Budget: $1858423
  • Program/Competition: Partner Programs
  • Genome Centre(s): Genome British Columbia
  • Fiscal Year: 2012
  • Status: Active

Glioblastoma (GBM) is a deadly brain cancer that has eluded major treatment advances. While all agree that new therapies for GBM are needed, there is no consensus on how best to find them. This project capitalizes on a method of growing stem cells from the brain called brain tumor initiating cells (BTICs), which are captured and retain the major genetic alterations that were present in the GBM tumors from which they were derived. This new cell-based model system is the foundation for an innovative drug discovery program with real potential for rapid clinical translation. This approach, which combines a superior model system with high-throughput drug screening and genomics technologies, holds great promise in identifying potential therapeutics, including those re-purposed from other indications.