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sector_ico_Health_trans Human Health

Inhibitors of the CBX7-H3K27me3 epigenetic interaction for castration resistant prostate cancer

CDR009
  • Project Leaders: Fraser Hof
  • Institutions: University of Victoria (UVic)
  • Budget: $139600
  • Program/Competition: Other Programs
  • Genome Centre(s): Genome British Columbia
  • Fiscal Year: 2014
  • Status: Closed

Prostate cancer is the most commonly diagnosed non-skin cancer in Canadian men, with an estimated 26,500 new cases in 2012. Current treatment options for castration-resistant prostate cancer offer only a 6-8 month increase in overall survival. This project’s goal was to identify compounds that inhibit the function of CBX7, a protein implicated in castration-resistant prostate cancer, with the ultimate goal of creating a novel treatment. The project established a CBX7 assay and tested potential inhibitors that they designed using multiple computational approaches.