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sector_ico_Health_trans Human Health

Inhibitors of New Delhi Metallo-B-Lactamase 1

  • Project Leaders: Natalie Strynadka
  • Institutions: University of British Columbia (UBC)
  • Budget: $180510
  • Program/Competition: Other Programs
  • Genome Centre(s): Genome British Columbia
  • Status: Closed

Antibiotic resistance in pathogenic microoganisms is now regarded to be a major threat to human health. One of the most worrying examples of this problem is the rapid emergence and international dissemination of a new enzyme called New Delhi Metallo-β-lactamase 1 (NDM-1), which makes bacteria resistant to a broad range of common antibiotics. The goal of this project was to develop NDM-1 inhibitors to combat NDM-1 positive bacterial strains. These inhibitors will hopefully restore the efficacy of antibiotics in NDM-1 positive strains. The team completed screening of 175,000 compounds. Additional research is anticipated to modify the screening assay before continuing the screening effort.