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Antibiotic resistance in pathogenic microoganisms is now regarded to be a major threat to human health. One of the most worrying examples of this problem is the rapid emergence and international dissemination of a new enzyme called New Delhi Metallo-β-lactamase 1 (NDM-1), which makes bacteria resistant to a broad range of common antibiotics. The goal of this project was to develop NDM-1 inhibitors to combat NDM-1 positive bacterial strains. These inhibitors will hopefully restore the efficacy of antibiotics in NDM-1 positive strains. The team completed screening of 175,000 compounds. Additional research is anticipated to modify the screening assay before continuing the screening effort.