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In the province of British Columbia, each year thousands of patients with genetic disorders require access to complex genetic tests that currently must be performed in laboratories outside of Canada. Building genomic diagnostic capacity within Canada will improve our understanding of these and other genetic disorders, as well as enhance the care of impacted patients and families. This project aims to evaluate the feasibility of integrating whole genome sequencing into standard of care for BC’s rare disease patients while facilitating the system changes necessary to achieve this anticipated future state. To accomplish this, the Provincial Health Services Authority’s Genome Diagnostics Laboratory and Provincial Medical Genetics Program, based at BC Children’s and BC Women’s Hospitals, will collaborate to introduce clinical whole genome sequencing diagnostics to a subset of patients with rare diseases under a pilot project, as well as collaborate with UBC to perform the necessary health economic assessment to inform this feasibility study. This project will also identify and support the development of processes requiring further resources and education while outlining policies involving inter-laboratory knowledge sharing, clinic-lab collaboration and stakeholder engagement. This project is made possible through the support of the Provincial Health Services Authority, Genome Canada, Genome BC, and Illumina, Inc. The deliverables of this project will support implementation of BC’s broader genomic strategy.