The project aimed at addressing the ongoing issue of multidrug-resistant (MDR) bacterial pathogens. The main goal of this project was to identify novel drug targets and therapeutics for antibiotic-resistant nosocomial pathogens.
Although two compounds with potential for development were identified as therapeutics for gram-negative bacteria*, these compounds were not pursued further by this project team.
*Gram-negative bacteria cause infections including pneumonia, bloodstream infections, wound or surgical site infections, and meningitis in healthcare settings. These bacteria can become resistant to multiple drugs and are increasingly resistant to currently available antibiotics.