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sector_ico_Health_trans Human Health

Identification of Novel Broad-Spectrum Drug Targets and Small Molecule Inhibitors for Antibiotic-Resistant Gram-negative Pathogens using a Revolutionary Indel-Targeting Approach

  • Project Leaders: Neil Reiner, Fiona Brinkman
  • Institutions: University of British Columbia (UBC)
  • Budget: $413430
  • Program/Competition: Proof of Concept
  • Genome Centre(s): Genome British Columbia
  • Status: Closed

The project aimed at addressing the ongoing issue of multidrug-resistant (MDR) bacterial pathogens. The main goal of this project was to identify novel drug targets and therapeutics for antibiotic-resistant nosocomial pathogens.

Although two compounds with potential for development were identified as therapeutics for gram-negative bacteria*, these compounds were not pursued further by this project team.

*Gram-negative bacteria cause infections including pneumonia, bloodstream infections, wound or surgical site infections, and meningitis in healthcare settings. These bacteria can become resistant to multiple drugs and are increasingly resistant to currently available antibiotics.