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sector_ico_Health_trans Health

Identification of Modulators of the Mesenchymal Progenitor Cell Phenotype

  • Project Leaders: Michael Underhill
  • Institutions: University of British Columbia (UBC)
  • Budget: $140650
  • Program/Competition: Other Programs
  • Genome Centre(s): Genome British Columbia
  • Status: Closed

This project’s goal is to screen 175,000 compounds to identify agents that promote mesenchymal progenitor (MP) quiescence using increased Hic1 expression as a surrogate marker. 60 analogues displayed no or little activation of Hic1 expression relative to their parent compound. Insights with regards to the mechanism of action were revealed and final report has been submitted. A proposal for a third iteration has been developed and will be presented to the IF partners for funding. This proposal was to further define the mechanism of action and potentially identify the target