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sector_ico_Health_trans Human Health

COVID-19 Sequencing and Modelling Integrated with Laboratory and Epidemiological Sources (SMILES)

  • Project Leaders: Agatha Jassem
  • Institutions: University of British Columbia (UBC)
  • Budget: $200000
  • Program/Competition: Rapid SARS-CoV-2 Vaccine Research Initiative in BC
  • Genome Centre(s): Genome British Columbia
  • Fiscal Year: 2021
  • Status: Closed

Vaccine escape mutants have the potential to undermine the effectiveness of the global vaccination campaign against SARS-CoV-2. The team will develop a surveillance program to detect and sequence viral variants emerging from vaccine breakthrough infections. These mutants will be tested experimentally to understand their responsiveness to vaccine-induced immunity, and modeling will be incorporated to project the impacts of vaccine escape mutants on transmission and pandemic progression in BC.