Big data genomics is becoming a disruptive technology that is impacting a range of industries in Canada. Technological innovations have made it easier to create and manage big data. This project will explore the relationship between data innovation, technology development, and social change in the making of big data genomic science. It will explore the role of communicative mechanisms between stakeholders developing big data technologies, such as the tension between data scientists and domain experts. The team will examine the socio-technical development and adoption of big data by a group of stakeholders involved in the Personalized Onco-Genomics (POG) initiative at the BC Cancer Research Centre and Genome Sciences Centre in Vancouver, BC. The network of stakeholders at POG/GSC are made of a network of stakeholders collaborating to innovate a cutting edge approach to mining different types of data, including genomic data, to reach their goals.