Genome British Columbia - Genome Genomics

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‘Live vaccines’: Recoding bacteria’s genome could lead to more effective immunizations

Geneticists used a new technique to recode 5 per cent of the Salmonella bacterium’s genome, introducing a record number of engineered changes into a single organism. A team led by [Jeffrey Way and Yu Heng Lau at Harvard University’s Wyss Institute]…has already made more than 1550 codon changes in 176 genes in a strain of Salmonella.

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